BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/20/2025- NAV $74.97
- NAV Change $-1.39
- Market Price $74.98
- Market Price Change $-1.42
- Trading Volume (M) 33,107
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/20/2025- NAV $74.97
- NAV Change $-1.39
- Market Price $74.98
- Market Price Change $-1.42
- Trading Volume (M) 33,107
- 30-Day Median Bid Ask Spread 0.29%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2025. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/20/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.30% | AMGN | AMGEN INC | -- | $4,212,502.56 | 12,624 | 2023607 |
| 5.06% | GILD | GILEAD SCIENCES INC | -- | $4,019,553.41 | 32,159 | 2369174 |
| 4.94% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,924,197.44 | 9,292 | 2931034 |
| 4.21% | REGN | REGENERON PHARMACEUTICALS | -- | $3,343,032.00 | 4,536 | 2730190 |
| 3.20% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,544,569.32 | 5,708 | B00FWN1 |
| 2.54% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,015,962.44 | 22,733 | 2989044 |
| 2.33% | INSM | INSMED INC | -- | $1,853,058.48 | 9,282 | 2614487 |
| 1.55% | ARGX | ARGENX SE - ADR | -- | $1,231,708.50 | 1,341 | BDVLM39 |
| 1.36% | BIIB | BIOGEN INC | -- | $1,082,742.84 | 6,438 | 2455965 |
| 1.19% | UTHR | UNITED THERAPEUTICS CORP | -- | $942,319.20 | 1,985 | 2430412 |
| 1.10% | INCY | INCYTE CORP | -- | $872,388.48 | 8,573 | 2471950 |
| 1.01% | ILMN | ILLUMINA INC | -- | $804,647.22 | 6,747 | 2613990 |
| 0.92% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $728,565.42 | 18,978 | BMVP7Y0 |
| 0.91% | MEDP | MEDPACE HOLDINGS INC | -- | $723,907.60 | 1,235 | BDCBC61 |
| 0.76% | ROIV | ROIVANT SCIENCES LTD | -- | $607,654.06 | 29,978 | BMW4NZ9 |
| 0.76% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $604,701.98 | 4,351 | 2623911 |
| 0.72% | SNY | SANOFI-ADR | -- | $575,973.09 | 11,781 | 2964557 |
| 0.72% | RVMD | REVOLUTION MEDICINES INC | -- | $573,435.28 | 8,206 | BL71K91 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $559,079.40 | 2,668 | BV9G6B8 |
| 0.69% | GH | GUARDANT HEALTH INC | -- | $549,343.10 | 5,477 | BFXC911 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $542,032.56 | 8,388 | BK1KWG8 |
| 0.68% | SMMT | SUMMIT THERAPEUTICS INC | -- | $536,450.95 | 32,611 | BMTVQS7 |
| 0.67% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $529,109.12 | 976 | BD59BS7 |
| 0.66% | VTRS | VIATRIS INC | -- | $521,503.82 | 51,178 | BMWS3X9 |
| 0.65% | ONC | BEONE MEDICINES LTD-ADR | -- | $515,202.75 | 1,475 | BYYWPW6 |
| 0.64% | IONS | IONIS PHARMACEUTICALS INC | -- | $511,328.16 | 6,993 | BDJ0LS6 |
| 0.62% | EXEL | EXELIXIS INC | -- | $493,672.48 | 11,816 | 2576941 |
| 0.61% | TEM | TEMPUS AI INC | -- | $486,434.45 | 7,405 | BSLSJJ0 |
| 0.59% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $467,468.40 | 2,660 | B4Q5ZN4 |
| 0.56% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $442,353.92 | 8,429 | 2437071 |
| 0.54% | BNTX | BIONTECH SE-ADR | -- | $428,025.58 | 4,414 | BK6H543 |
| 0.50% | RNA | AVIDITY BIOSCIENCES INC | -- | $398,960.55 | 5,647 | BMWHPY1 |
| 0.48% | MRNA | MODERNA INC | -- | $381,908.80 | 17,080 | BGSXTS3 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $354,091.98 | 5,134 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $333,692.50 | 5,255 | BBBSBJ5 |
| 0.40% | MRUS | MERUS NV | -- | $318,461.64 | 3,318 | BZBY005 |
| 0.40% | NUVL | NUVALENT INC-A | -- | $316,145.27 | 2,927 | BMVBZD3 |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $314,135.52 | 2,192 | BYZR4X4 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $293,725.88 | 2,918 | BF2YWG4 |
| 0.34% | PCVX | VAXCYTE INC | -- | $271,719.00 | 5,700 | BKPVGH6 |
| 0.34% | PTCT | PTC THERAPEUTICS INC | -- | $266,921.86 | 3,491 | B17VCN9 |
| 0.33% | KRYS | KRYSTAL BIOTECH INC | -- | $258,957.30 | 1,268 | BD6JX35 |
| 0.29% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $231,244.39 | 6,071 | BYQBFJ8 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $229,781.80 | 2,729 | BDCBCD8 |
| 0.27% | ACLX | ARCELLX INC | -- | $217,923.81 | 2,433 | BPCJ1Q2 |
| 0.27% | COGT | COGENT BIOSCIENCES INC | -- | $212,884.50 | 6,135 | BLR6XK8 |
| 0.26% | ALKS | ALKERMES PLC | -- | $204,321.12 | 7,248 | B3P6D26 |
| 0.26% | KYMR | KYMERA THERAPEUTICS INC | -- | $202,938.20 | 3,140 | BMPRZV5 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $196,617.81 | 3,989 | BDHF4K6 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $190,455.76 | 3,512 | BK7Y2V9 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $186,325.11 | 4,941 | BP8JSP4 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $174,320.71 | 7,649 | BJRFSB7 |
| 0.22% | INDV | INDIVIOR PLC | -- | $174,067.83 | 5,479 | BP0BQQ5 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $173,378.07 | 4,131 | BDD19F8 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $171,563.86 | 862 | 2501578 |
| 0.22% | ADMA | ADMA BIOLOGICS INC | -- | $171,387.36 | 10,476 | B9NSBM2 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $169,597.40 | 7,406 | 2713317 |
| 0.20% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $160,558.46 | 4,223 | BFZQ0L8 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $158,757.31 | 13,787 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $152,497.80 | 2,205 | BJDX8Y8 |
| 0.19% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $152,111.43 | 927 | BQ721R4 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $143,892.45 | 5,265 | BKX9VD3 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $142,489.98 | 1,851 | BMH5RL1 |
| 0.18% | VCYT | VERACYTE INC | -- | $141,055.05 | 3,453 | BFTWZY0 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $138,054.80 | 1,528 | BMGJZJ8 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $136,378.50 | 3,350 | BRBCSP4 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $136,233.41 | 3,383 | BRJ3GY4 |
| 0.17% | GRAL | GRAIL INC | -- | $135,840.90 | 1,586 | BSLSSX7 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $135,794.30 | 3,910 | BLFGJD5 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $131,984.94 | 4,233 | BJ62Z18 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $128,450.99 | 2,027 | BM9HHL5 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $127,896.30 | 13,534 | B19FQ48 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $127,467.04 | 3,844 | BK0VHF6 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $125,629.28 | 6,244 | BN15WD1 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $121,967.31 | 2,913 | BP9N0G0 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $115,888.32 | 4,208 | BLB0YQ9 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $110,407.35 | 2,465 | B72ZBG4 |
| 0.14% | DNLI | DENALI THERAPEUTICS INC | -- | $110,201.52 | 6,422 | BD2B4V0 |
| 0.14% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $109,066.56 | 6,683 | BJ5FZ74 |
| 0.14% | APLS | APELLIS PHARMACEUTICALS INC | -- | $108,388.38 | 5,547 | BYTQ6X1 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $102,884.00 | 4,624 | BKY5JZ8 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $101,668.29 | 3,693 | BMX9K07 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $100,210.18 | 3,838 | BMDJ0C9 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $97,747.34 | 4,261 | BDGMC59 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $91,546.40 | 4,444 | BK6L288 |
| 0.11% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $89,902.12 | 2,618 | BQS9486 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $89,505.64 | 7,637 | BNZB1X8 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $87,509.20 | 5,780 | BFWLC09 |
| 0.11% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $84,209.58 | 2,522 | BKSGZN7 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $83,819.90 | 41,495 | BNSP0B8 |
| 0.11% | VCEL | VERICEL CORP | -- | $83,762.05 | 2,213 | BSBMN89 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $82,727.96 | 5,026 | BKS3RS7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $79,162.92 | 1,908 | BRXB0C0 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $78,606.00 | 3,300 | BPCQZY9 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $78,036.00 | 2,800 | BL55460 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $75,420.42 | 2,638 | BMFX8Y7 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $74,751.04 | 952 | BCDWBX6 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $72,222.15 | 18,759 | BM9FJ13 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $70,748.64 | 4,293 | B8DPDT7 |
| 0.09% | ALVO | ALVOTECH SA | -- | $69,509.22 | 13,737 | BPNTJ34 |
| 0.09% | TWST | TWIST BIOSCIENCE CORP | -- | $69,059.43 | 2,649 | BGKG6G7 |
| 0.09% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $68,579.58 | 1,758 | BLCD809 |
| 0.08% | QURE | UNIQURE NV | -- | $67,378.50 | 2,415 | BJFSR88 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $67,227.51 | 2,407 | BJQ05Z6 |
| 0.08% | MNKD | MANNKIND CORP | -- | $66,950.87 | 13,471 | BF081J4 |
| 0.08% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $66,294.12 | 3,012 | BMZ4LN0 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $64,795.51 | 9,217 | 2100362 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $64,534.25 | 3,785 | BN7Q7R7 |
| 0.08% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $62,702.64 | 2,552 | BCBVTX1 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $62,195.50 | 2,650 | BQBBDY8 |
| 0.08% | HROW | HARROW INC | -- | $61,122.18 | 1,623 | BHNDW86 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $60,826.80 | 1,384 | BX7RSN3 |
| 0.07% | ARDX | ARDELYX INC | -- | $58,696.80 | 10,576 | BN89V40 |
| 0.07% | INVA | INNOVIVA INC | -- | $58,592.04 | 2,769 | BDDXF67 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $56,934.90 | 5,346 | BJH9ZN0 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $56,245.68 | 4,908 | BYSS4X4 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $55,576.80 | 5,146 | BRJZSK0 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $55,273.60 | 1,840 | BBC9WC7 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $55,238.19 | 2,597 | BMFD115 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $53,072.27 | 3,911 | BPCK358 |
| 0.07% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $51,759.76 | 2,041 | BNFWZS4 |
| 0.06% | NRIX | NURIX THERAPEUTICS INC | -- | $51,478.14 | 3,358 | BMVLGP2 |
| 0.06% | PGEN | PRECIGEN INC | -- | $51,000.30 | 13,077 | BKM5C84 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $50,937.92 | 638 | BNSP8K3 |
| 0.06% | CVAC | CUREVAC NV | -- | $50,611.20 | 9,885 | BN4RD42 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $50,499.72 | 2,033 | BZ7PJQ1 |
| 0.06% | TYRA | TYRA BIOSCIENCES INC | -- | $49,203.00 | 2,343 | BMVNDH9 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,927.76 | 4,262 | BKVDFF7 |
| 0.06% | XNCR | XENCOR INC | -- | $48,796.48 | 3,133 | BGCYWN8 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,502.44 | 7,091 | BLR7H87 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $48,277.46 | 7,567 | BN2R582 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $47,768.28 | 11,972 | BNC1BX1 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $47,176.92 | 6,984 | BYZG9R0 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $46,359.46 | 1,231 | BDRW1L7 |
| 0.06% | CSTL | CASTLE BIOSCIENCES INC | -- | $45,364.40 | 1,270 | BKLCWZ3 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $45,142.65 | 5,355 | B8K7T65 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $44,984.40 | 1,973 | B3X26D8 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $44,735.79 | 13,119 | BL53SR3 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $44,659.60 | 3,110 | BJLKVS6 |
| 0.06% | NVAX | NOVAVAX INC | -- | $44,336.16 | 7,128 | BJDQXG4 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $44,263.60 | 1,640 | BKVF0J2 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $43,494.30 | 4,887 | BP2P6L0 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $43,040.55 | 1,603 | BR3T9B6 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $42,481.42 | 2,102 | BD9GVY0 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $41,833.80 | 3,810 | BYZD465 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $41,274.64 | 3,026 | BMGS7L1 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $39,989.32 | 3,983 | BRXYZ57 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $39,559.00 | 2,210 | BMNDK09 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $37,868.40 | 4,710 | BYZM6C2 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $37,255.26 | 4,494 | BLB0YH0 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $36,683.11 | 11,357 | BMFJJ97 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $36,652.72 | 2,711 | BP7KZP7 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,443.33 | 893 | BL95N25 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $36,382.72 | 3,344 | BPQYY97 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $35,686.74 | 1,779 | BMGTLY5 |
| 0.04% | ARVN | ARVINAS INC | -- | $35,517.46 | 3,223 | BDZ30Q0 |
| 0.04% | SVRA | SAVARA INC | -- | $35,449.97 | 7,591 | BYXGN81 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $35,351.40 | 8,417 | BZ0QMB7 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $34,677.72 | 1,251 | BQV0J03 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $34,633.66 | 15,887 | BF0DMK7 |
| 0.04% | ERAS | ERASCA INC | -- | $34,622.12 | 12,454 | BNLYBF3 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $34,589.76 | 789 | BQD3J33 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $33,899.32 | 6,097 | BK4PZ38 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,225.76 | 3,892 | BJQ0608 |
| 0.04% | CRMD | CORMEDIX INC | -- | $31,871.88 | 3,279 | BJ0LT31 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $30,895.29 | 3,429 | BDDVW37 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $30,863.55 | 2,479 | BMYRFN8 |
| 0.04% | GERN | GERON CORP | -- | $30,807.70 | 28,007 | 2370381 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $29,939.60 | 1,780 | BM7V485 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $29,825.34 | 5,307 | BYVQJ96 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $29,642.40 | 2,070 | BQS7491 |
| 0.04% | ALMS | ALUMIS INC | -- | $29,430.76 | 4,253 | BPLQG36 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $29,188.01 | 4,337 | BMCR7V2 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $28,761.18 | 2,209 | BD06CS0 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $28,331.82 | 7,678 | BPBJFM7 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $27,861.74 | 3,274 | BYP80F1 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,227.90 | 3,530 | BFYQFJ2 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $26,116.35 | 8,853 | BBNBTD2 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $24,791.56 | 13,187 | B4N8MH9 |
| 0.03% | OMER | OMEROS CORP | -- | $24,599.47 | 2,989 | B4NB858 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,077.05 | 2,215 | BZ0G875 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,728.05 | 2,361 | B91XRN2 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,595.76 | 7,128 | B3MZ6K5 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $22,584.80 | 2,590 | BM90J52 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $22,326.35 | 2,467 | BLFBZ32 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $21,730.68 | 6,354 | BMCWKZ2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,197.00 | 2,050 | BKLXFX5 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,098.88 | 2,368 | BQ6C357 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $21,061.92 | 15,956 | BWFZX59 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $20,940.40 | 4,027 | BMC3HS7 |
| 0.03% | ANNX | ANNEXON INC | -- | $20,602.75 | 4,825 | BMVV9R5 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $19,667.13 | 2,499 | BMFK3H6 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,355.70 | 1,365 | BYXV9H7 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,111.68 | 632 | B292NQ7 |
| 0.02% | EOLS | EVOLUS INC | -- | $18,814.04 | 2,842 | BDRJH21 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,190.59 | 6,567 | BN94K69 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,140.88 | 3,144 | 2107437 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $17,325.72 | 3,876 | BFY7DC4 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $16,777.24 | 7,109 | BN4JN37 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $15,332.24 | 1,672 | BP81RK8 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $15,257.66 | 3,421 | BQHN6C7 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $14,809.20 | 820 | BPBPCG8 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $14,763.21 | 847 | BTNMG41 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,578.75 | 2,725 | BP81R42 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $14,524.12 | 884 | BN72KB0 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $14,128.56 | 1,899 | BSMLR16 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,461.60 | 4,740 | BDFKQ07 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,087.35 | 2,061 | BL5B6Z1 |
| 0.02% | NGNE | NEUROGENE INC | -- | $12,852.00 | 630 | BS2F741 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,824.37 | 4,407 | BZC0D70 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,654.35 | 3,755 | BMXNGZ6 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $12,540.44 | 2,591 | B12W3P6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,537.44 | 2,032 | BKDQKM6 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $12,326.13 | 2,721 | BLBR8D5 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $12,078.84 | 9,741 | BFZNYB7 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $11,941.39 | 3,767 | BYTYP72 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $11,402.20 | 940 | B9L5200 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,396.97 | 2,483 | BMF7DT9 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $10,828.92 | 8,804 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,461.00 | 3,487 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,394.33 | 2,349 | BP7L561 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,950.97 | 2,433 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,754.03 | 3,949 | BZ8FPH3 |
| 0.01% | OABI | OMNIAB INC | -- | $8,989.61 | 5,383 | BN13S71 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,186.75 | 1,145 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,788.48 | 6,954 | BMYTJP4 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,630.03 | 4,681 | BKMQF66 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,442.26 | 3,127 | BKX9NQ0 |
| 0.01% | PEPG | PEPGEN INC | -- | $7,344.87 | 1,443 | BMTX3D7 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,021.00 | 1,190 | BKC9SX3 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,220.34 | 3,962 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,024.69 | 219 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,401.06 | 3,122 | BK80YJ8 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,335.20 | 4,446 | BJ4LDC4 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,151.94 | 2,978 | BMW5LX6 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,062.00 | 5,062 | BCZS820 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,207.32 | 2,697 | BMDWW66 |
| -- | MGNX | MACROGENICS INC | -- | $3,803.12 | 2,776 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,569.67 | 8,637 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,407.75 | 1,075 | BMF1LJ7 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,151.89 | 3,723 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,123.32 | 1,382 | BP2TPK4 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,615.00 | 2,615 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,265.96 | 2,300 | BNLYBJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,769.53 | 6,304 | BJL38Z1 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,482.92 | 566 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,028.69 | 533 | BS2FKQ4 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 36.31% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 28,850,852 | -- | 5,238 | -- |
| 35.32% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,068,717 | -- | 5,096 | -- |
| 21.31% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 16,937,069 | -- | 3,075 | -- |
| 17.22% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,681,847 | -- | 2,484 | -- |
| 15.94% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,662,869 | -- | 2,299 | -- |
| 8.01% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,361,728 | -- | 1,155 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $26,695,731.53 | 26,695,732 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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