BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/17/2025- NAV $76.70
- NAV Change $+1.31
- Market Price $76.73
- Market Price Change $+1.25
- Trading Volume (M) 35,774
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/17/2025- NAV $76.70
- NAV Change $+1.31
- Market Price $76.73
- Market Price Change $+1.25
- Trading Volume (M) 35,774
- 30-Day Median Bid Ask Spread 0.28%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2025. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/17/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.21% | AMGN | AMGEN INC | -- | $4,078,650.56 | 11,936 | 2023607 |
| 4.87% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,812,431.68 | 8,784 | 2931034 |
| 4.82% | GILD | GILEAD SCIENCES INC | -- | $3,772,708.27 | 30,403 | 2369174 |
| 3.86% | REGN | REGENERON PHARMACEUTICALS | -- | $3,020,081.28 | 4,288 | 2730190 |
| 3.18% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,485,073.84 | 5,396 | B00FWN1 |
| 2.46% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,921,474.20 | 21,493 | 2989044 |
| 2.21% | INSM | INSMED INC | -- | $1,731,987.60 | 8,774 | 2614487 |
| 1.51% | ARGX | ARGENX SE - ADR | -- | $1,179,675.09 | 1,269 | BDVLM39 |
| 1.28% | BIIB | BIOGEN INC | -- | $1,002,242.48 | 6,086 | 2455965 |
| 1.13% | UTHR | UNITED THERAPEUTICS CORP | -- | $885,793.84 | 1,877 | 2430412 |
| 1.08% | INCY | INCYTE CORP | -- | $844,297.85 | 8,105 | 2471950 |
| 0.98% | ILMN | ILLUMINA INC | -- | $765,990.32 | 6,379 | 2613990 |
| 0.90% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $702,608.72 | 17,942 | BMVP7Y0 |
| 0.87% | MEDP | MEDPACE HOLDINGS INC | -- | $683,581.92 | 1,167 | BDCBC61 |
| 0.76% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $590,749.40 | 4,115 | 2623911 |
| 0.74% | ROIV | ROIVANT SCIENCES LTD | -- | $582,711.52 | 28,342 | BMW4NZ9 |
| 0.74% | SNY | SANOFI-ADR | -- | $576,673.86 | 11,137 | 2964557 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $546,597.44 | 2,524 | BV9G6B8 |
| 0.69% | RVMD | REVOLUTION MEDICINES INC | -- | $536,388.12 | 7,758 | BL71K91 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $530,650.80 | 7,932 | BK1KWG8 |
| 0.67% | ONC | BEONE MEDICINES LTD-ADR | -- | $525,398.85 | 1,395 | BYYWPW6 |
| 0.67% | SMMT | SUMMIT THERAPEUTICS INC | -- | $522,585.45 | 30,831 | BMTVQS7 |
| 0.66% | VTRS | VIATRIS INC | -- | $515,794.76 | 48,386 | BMWS3X9 |
| 0.65% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $511,360.08 | 924 | BD59BS7 |
| 0.64% | GH | GUARDANT HEALTH INC | -- | $499,476.96 | 5,177 | BFXC911 |
| 0.62% | IONS | IONIS PHARMACEUTICALS INC | -- | $484,468.38 | 6,613 | BDJ0LS6 |
| 0.61% | EXEL | EXELIXIS INC | -- | $473,916.24 | 11,172 | 2576941 |
| 0.59% | TEM | TEMPUS AI INC | -- | $464,796.39 | 7,001 | BSLSJJ0 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $433,991.74 | 7,969 | 2437071 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $428,544.58 | 4,174 | BK6H543 |
| 0.55% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $427,946.44 | 2,516 | B4Q5ZN4 |
| 0.51% | MRNA | MODERNA INC | -- | $399,824.48 | 16,148 | BGSXTS3 |
| 0.48% | RNA | AVIDITY BIOSCIENCES INC | -- | $377,360.52 | 5,339 | BMWHPY1 |
| 0.44% | HALO | HALOZYME THERAPEUTICS INC | -- | $342,498.24 | 4,854 | 2975098 |
| 0.43% | CYTK | CYTOKINETICS INC | -- | $332,540.65 | 4,967 | BBBSBJ5 |
| 0.39% | AXSM | AXSOME THERAPEUTICS INC | -- | $301,600.32 | 2,072 | BYZR4X4 |
| 0.38% | MRUS | MERUS NV | -- | $300,871.44 | 3,138 | BZBY005 |
| 0.38% | NUVL | NUVALENT INC-A | -- | $298,836.00 | 2,767 | BMVBZD3 |
| 0.35% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $277,703.02 | 2,758 | BF2YWG4 |
| 0.33% | PCVX | VAXCYTE INC | -- | $260,455.92 | 5,388 | BKPVGH6 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $249,900.00 | 1,200 | BD6JX35 |
| 0.32% | PTCT | PTC THERAPEUTICS INC | -- | $249,404.40 | 3,299 | B17VCN9 |
| 0.29% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $230,420.85 | 5,739 | BYQBFJ8 |
| 0.28% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $218,791.37 | 2,581 | BDCBCD8 |
| 0.27% | CRSP | CRISPR THERAPEUTICS AG | -- | $208,722.36 | 3,773 | BDHF4K6 |
| 0.27% | ACLX | ARCELLX INC | -- | $207,872.34 | 2,301 | BPCJ1Q2 |
| 0.26% | ALKS | ALKERMES PLC | -- | $200,969.16 | 6,852 | B3P6D26 |
| 0.25% | COGT | COGENT BIOSCIENCES INC | -- | $195,716.25 | 5,799 | BLR6XK8 |
| 0.24% | KYMR | KYMERA THERAPEUTICS INC | -- | $190,248.80 | 2,968 | BMPRZV5 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $180,442.00 | 3,320 | BK7Y2V9 |
| 0.23% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $180,190.88 | 4,673 | BP8JSP4 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $175,761.90 | 7,233 | BJRFSB7 |
| 0.22% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $172,882.50 | 875 | BQ721R4 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $170,032.64 | 3,907 | BDD19F8 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $168,118.02 | 7,002 | 2713317 |
| 0.21% | LGND | LIGAND PHARMACEUTICALS | -- | $163,898.90 | 814 | 2501578 |
| 0.21% | INDV | INDIVIOR PLC | -- | $162,517.02 | 5,179 | BP0BQQ5 |
| 0.20% | ADMA | ADMA BIOLOGICS INC | -- | $152,719.68 | 9,904 | B9NSBM2 |
| 0.19% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $150,945.30 | 13,035 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $150,557.85 | 2,085 | BJDX8Y8 |
| 0.19% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $145,551.77 | 3,991 | BFZQ0L8 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $131,057.12 | 3,698 | BLFGJD5 |
| 0.17% | CGON | CG ONCOLOGY INC | -- | $130,597.50 | 3,166 | BRBCSP4 |
| 0.17% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $130,248.09 | 4,977 | BKX9VD3 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $130,192.54 | 4,001 | BJ62Z18 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $129,911.39 | 3,199 | BRJ3GY4 |
| 0.17% | TARS | TARSUS PHARMACEUTICALS INC | -- | $129,871.67 | 1,751 | BMH5RL1 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $129,454.60 | 1,444 | BMGJZJ8 |
| 0.16% | VCYT | VERACYTE INC | -- | $128,249.20 | 3,265 | BFTWZY0 |
| 0.16% | GRAL | GRAIL INC | -- | $127,240.12 | 1,498 | BSLSSX7 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $124,149.45 | 1,915 | BM9HHL5 |
| 0.16% | MLYS | MINERALYS THERAPEUTICS INC | -- | $121,847.78 | 2,753 | BP9N0G0 |
| 0.15% | IDYA | IDEAYA BIOSCIENCES INC | -- | $121,224.24 | 3,636 | BK0VHF6 |
| 0.15% | FOLD | AMICUS THERAPEUTICS INC | -- | $120,519.48 | 12,794 | B19FQ48 |
| 0.15% | DYN | DYNE THERAPEUTICS INC | -- | $119,496.96 | 5,904 | BN15WD1 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $108,853.56 | 2,412 | BCBVTX1 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $108,733.60 | 3,980 | BLB0YQ9 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $105,435.90 | 6,070 | BD2B4V0 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $105,384.30 | 5,243 | BYTQ6X1 |
| 0.13% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $105,014.61 | 2,329 | B72ZBG4 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $103,811.96 | 3,493 | BMX9K07 |
| 0.12% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $97,320.72 | 4,372 | BKY5JZ8 |
| 0.12% | TERN | TERNS PHARMACEUTICALS INC | -- | $92,782.80 | 3,630 | BMDJ0C9 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $92,747.58 | 4,029 | BDGMC59 |
| 0.12% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $92,626.56 | 2,474 | BQS9486 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $92,484.00 | 4,200 | BK6L288 |
| 0.11% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $86,633.49 | 6,319 | BJ5FZ74 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $85,857.69 | 7,221 | BNZB1X8 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $84,637.36 | 5,464 | BFWLC09 |
| 0.11% | VCEL | VERICEL CORP | -- | $82,526.99 | 2,093 | BSBMN89 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $81,100.14 | 2,386 | BKSGZN7 |
| 0.10% | IBRX | IMMUNITYBIO INC | -- | $79,638.93 | 39,231 | BNSP0B8 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $78,010.08 | 2,648 | BL55460 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $74,685.60 | 1,804 | BRXB0C0 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $74,575.00 | 4,750 | BKS3RS7 |
| 0.10% | ZYME | ZYMEWORKS INC | -- | $74,568.00 | 3,120 | BPCQZY9 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $73,773.00 | 900 | BCDWBX6 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $73,068.20 | 17,735 | BM9FJ13 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $71,627.68 | 2,494 | BMFX8Y7 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $71,159.78 | 4,057 | B8DPDT7 |
| 0.09% | QURE | UNIQURE NV | -- | $69,243.39 | 2,283 | BJFSR88 |
| 0.09% | ALVO | ALVOTECH SA | -- | $66,763.46 | 12,989 | BPNTJ34 |
| 0.08% | TWST | TWIST BIOSCIENCE CORP | -- | $66,282.30 | 2,505 | BGKG6G7 |
| 0.08% | MNKD | MANNKIND CORP | -- | $63,420.30 | 12,735 | BF081J4 |
| 0.08% | HROW | HARROW INC | -- | $61,845.15 | 1,535 | BHNDW86 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $61,452.86 | 3,577 | BN7Q7R7 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $61,311.25 | 2,275 | BJQ05Z6 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $61,252.39 | 8,713 | 2100362 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $61,046.16 | 2,506 | BQBBDY8 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $60,779.34 | 1,662 | BLCD809 |
| 0.08% | PGEN | PRECIGEN INC | -- | $60,588.50 | 12,365 | BKM5C84 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $59,304.72 | 1,308 | BX7RSN3 |
| 0.08% | ARDX | ARDELYX INC | -- | $59,100.00 | 10,000 | BN89V40 |
| 0.07% | INVA | INNOVIVA INC | -- | $57,495.49 | 2,617 | BDDXF67 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $57,362.90 | 5,054 | BJH9ZN0 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $54,207.24 | 4,866 | BRJZSK0 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $53,464.32 | 2,457 | BMFD115 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $52,930.80 | 1,740 | BBC9WC7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $52,292.80 | 4,640 | BYSS4X4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $51,712.02 | 3,699 | BPCK358 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $50,192.58 | 1,929 | BNFWZS4 |
| 0.06% | CVAC | CUREVAC NV | -- | $49,341.60 | 9,345 | BN4RD42 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $48,663.78 | 6,703 | BLR7H87 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,601.80 | 4,030 | BKVDFF7 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $47,366.10 | 7,155 | BN2R582 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $47,218.60 | 6,604 | BYZG9R0 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $46,638.40 | 11,320 | BNC1BX1 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $46,564.70 | 602 | BNSP8K3 |
| 0.06% | XNCR | XENCOR INC | -- | $46,250.82 | 2,961 | BGCYWN8 |
| 0.06% | NVAX | NOVAVAX INC | -- | $45,832.00 | 6,740 | BJDQXG4 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $45,527.70 | 1,921 | BZ7PJQ1 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $44,650.80 | 12,403 | BL53SR3 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $44,536.20 | 1,865 | B3X26D8 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $43,812.96 | 1,552 | BKVF0J2 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $43,035.50 | 5,063 | B8K7T65 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $42,394.22 | 2,942 | BJLKVS6 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $41,547.12 | 1,986 | BD9GVY0 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $40,807.90 | 1,202 | BKLCWZ3 |
| 0.05% | NRIX | NURIX THERAPEUTICS INC | -- | $40,595.46 | 3,174 | BMVLGP2 |
| 0.05% | ANAB | ANAPTYSBIO INC | -- | $40,437.51 | 1,163 | BDRW1L7 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $39,082.68 | 10,737 | BMFJJ97 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $39,081.70 | 3,602 | BYZD465 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $38,075.70 | 845 | BL95N25 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $38,041.65 | 1,515 | BR3T9B6 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $37,769.92 | 4,454 | BYZM6C2 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $37,703.60 | 2,090 | BMNDK09 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $37,592.37 | 2,862 | BMGS7L1 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $37,570.00 | 4,250 | BLB0YH0 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $36,878.93 | 3,767 | BRXYZ57 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $36,859.62 | 4,619 | BP2P6L0 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $36,345.98 | 15,019 | BF0DMK7 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $36,124.78 | 7,957 | BZ0QMB7 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $35,834.40 | 3,160 | BPQYY97 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $35,218.50 | 2,215 | BMVNDH9 |
| 0.04% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $34,882.43 | 2,563 | BP7KZP7 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $34,821.27 | 1,683 | BMGTLY5 |
| 0.04% | ERAS | ERASCA INC | -- | $33,791.38 | 11,774 | BNLYBF3 |
| 0.04% | ARVN | ARVINAS INC | -- | $33,638.88 | 3,047 | BDZ30Q0 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $31,669.95 | 745 | BQD3J33 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $31,649.85 | 5,765 | BK4PZ38 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $31,042.54 | 2,089 | BD06CS0 |
| 0.04% | CRMD | CORMEDIX INC | -- | $30,928.02 | 3,099 | BJ0LT31 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $30,403.10 | 1,183 | BQV0J03 |
| 0.04% | SVRA | SAVARA INC | -- | $30,135.00 | 7,175 | BYXGN81 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $30,019.32 | 4,101 | BMCR7V2 |
| 0.04% | GERN | GERON CORP | -- | $29,921.27 | 26,479 | 2370381 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $29,546.22 | 1,958 | BQS7491 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $29,451.51 | 2,343 | BMYRFN8 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $29,251.08 | 1,684 | BM7V485 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $29,210.58 | 5,019 | BYVQJ96 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $28,423.57 | 3,241 | BDDVW37 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $27,725.56 | 7,258 | BPBJFM7 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $27,567.54 | 3,094 | BYP80F1 |
| 0.04% | PSNL | PERSONALIS INC | -- | $27,526.40 | 3,680 | BJQ0608 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,303.44 | 3,338 | BFYQFJ2 |
| 0.03% | OMER | OMEROS CORP | -- | $25,651.00 | 2,825 | B4NB858 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $24,264.96 | 2,848 | BMZ4LN0 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $23,600.58 | 8,369 | BBNBTD2 |
| 0.03% | RGNX | REGENXBIO INC | -- | $23,338.30 | 2,095 | BZ0G875 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $22,888.25 | 2,233 | B91XRN2 |
| 0.03% | ALMS | ALUMIS INC | -- | $22,417.08 | 4,021 | BPLQG36 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $22,022.64 | 15,084 | BWFZX59 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $21,486.50 | 2,450 | BM90J52 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $21,398.58 | 2,331 | BLFBZ32 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,235.20 | 2,240 | BQ6C357 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $21,221.10 | 1,938 | BKLXFX5 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $21,096.20 | 6,740 | B3MZ6K5 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $20,291.31 | 3,807 | BMC3HS7 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $20,060.04 | 6,006 | BMCWKZ2 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $19,573.19 | 12,467 | B4N8MH9 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $18,986.97 | 1,289 | BYXV9H7 |
| 0.02% | EOLS | EVOLUS INC | -- | $18,667.70 | 2,686 | BDRJH21 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $18,332.96 | 596 | B292NQ7 |
| 0.02% | ABSI | ABSCI CORP | -- | $17,752.02 | 6,207 | BN94K69 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $17,557.09 | 2,363 | BMFK3H6 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $17,534.80 | 2,972 | 2107437 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $17,407.39 | 6,721 | BN4JN37 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $15,352.16 | 3,664 | BFY7DC4 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $14,262.88 | 776 | BPBPCG8 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,173.50 | 2,577 | BP81R42 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $14,031.22 | 3,233 | BQHN6C7 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $13,918.58 | 799 | BTNMG41 |
| 0.02% | ANNX | ANNEXON INC | -- | $13,774.22 | 4,561 | BMVV9R5 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,619.20 | 4,480 | BDFKQ07 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $13,409.44 | 836 | BN72KB0 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $13,382.60 | 1,580 | BP81RK8 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,341.24 | 594 | BS2F741 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,058.30 | 1,949 | BL5B6Z1 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $12,917.70 | 4,167 | BZC0D70 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $12,852.20 | 1,795 | BSMLR16 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $12,755.54 | 3,563 | BYTYP72 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,535.03 | 3,551 | BMXNGZ6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,403.20 | 1,920 | BKDQKM6 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $11,964.45 | 2,573 | BLBR8D5 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $11,384.16 | 888 | B9L5200 |
| 0.01% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $11,327.07 | 9,209 | BFZNYB7 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $11,289.07 | 2,347 | BMF7DT9 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,154.16 | 8,324 | BFMLGR4 |
| 0.01% | VNDA | VANDA PHARMACEUTICALS INC | -- | $10,784.40 | 2,451 | B12W3P6 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $9,950.90 | 3,295 | BLN9Z50 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,631.14 | 3,733 | BZ8FPH3 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $9,505.88 | 2,221 | BP7L561 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $9,457.11 | 2,301 | BY7RB53 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $7,977.78 | 1,081 | BQB9HM8 |
| 0.01% | OABI | OMNIAB INC | -- | $7,738.32 | 5,091 | BN13S71 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,611.76 | 1,126 | BKC9SX3 |
| 0.01% | HUMA | HUMACYTE INC | -- | $7,428.62 | 6,574 | BMYTJP4 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,387.50 | 2,955 | BKX9NQ0 |
| 0.01% | PEPG | PEPGEN INC | -- | $7,292.05 | 1,363 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,212.75 | 4,425 | BKMQF66 |
| 0.01% | CDXS | CODEXIS INC | -- | $5,881.22 | 3,746 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $5,738.04 | 207 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,339.50 | 2,950 | BK80YJ8 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,290.32 | 2,814 | BMW5LX6 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,210.48 | 4,202 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $4,656.78 | 4,786 | BCZS820 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $4,205.85 | 2,549 | BMDWW66 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,962.24 | 2,624 | BFDV8K0 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,562.65 | 1,015 | BMF1LJ7 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,159.04 | 8,165 | BPG5P75 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,108.28 | 1,306 | BP2TPK4 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,991.50 | 3,519 | BF12XC2 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,866.36 | 2,471 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,110.72 | 2,176 | BNLYBJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,693.83 | 5,960 | BJL38Z1 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,687.44 | 534 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,156.45 | 505 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 36.28% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,382,580 | -- | 5,096 | -- |
| 34.92% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 27,318,790 | -- | 4,905 | -- |
| 21.89% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 17,126,459 | -- | 3,075 | -- |
| 17.68% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,834,837 | -- | 2,484 | -- |
| 16.37% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,804,464 | -- | 2,299 | -- |
| 8.22% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,432,865 | -- | 1,155 | -- |
| -- | -- | TREASURY BILL | -- | $4,998,940.20 | 5,000,000 | BMGHP58 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $22,760,316.99 | 22,760,317 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
Read More