BIB seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 10/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB NAV | 20.05% | 41.93% | 51.59% | 42.58% | 20.67% | 9.55% | 2.60% | 0.91% | 15.79% | 04/07/2010 |
| BIB Market Price | 20.06% | 42.12% | 51.73% | 42.51% | 20.92% | 9.51% | 2.55% | 0.91% | 15.79% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 8.14% | 30.45% | 24.49% | 18.70% | -4.97% | 8.65% | -2.66% | 0.48% | 14.52% | 04/07/2010 |
| BIB NAV | 8.12% | 30.51% | 24.65% | 18.77% | -5.03% | 8.69% | -2.70% | 0.43% | 14.52% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/19/2025- NAV $76.36
- NAV Change $-1.45
- Market Price $76.39
- Market Price Change $-1.52
- Trading Volume (M) 11,280
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.19%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 11/19/2025- NAV $76.36
- NAV Change $-1.45
- Market Price $76.39
- Market Price Change $-1.52
- Trading Volume (M) 11,280
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2025. Without the fee waiver performance would likely be lower.
Exposures
Index as of 9/30/2025
Holdings
as of 11/19/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.34% | AMGN | AMGEN INC | -- | $4,322,457.60 | 12,624 | 2023607 |
| 5.09% | GILD | GILEAD SCIENCES INC | -- | $4,118,603.13 | 32,159 | 2369174 |
| 4.83% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $3,912,210.76 | 9,292 | 2931034 |
| 3.93% | REGN | REGENERON PHARMACEUTICALS | -- | $3,183,682.32 | 4,536 | 2730190 |
| 3.25% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,630,018.08 | 5,708 | B00FWN1 |
| 2.50% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $2,023,009.67 | 22,733 | 2989044 |
| 2.33% | INSM | INSMED INC | -- | $1,889,443.92 | 9,282 | 2614487 |
| 1.52% | ARGX | ARGENX SE - ADR | -- | $1,226,465.19 | 1,341 | BDVLM39 |
| 1.34% | BIIB | BIOGEN INC | -- | $1,081,133.34 | 6,438 | 2455965 |
| 1.17% | UTHR | UNITED THERAPEUTICS CORP | -- | $945,931.90 | 1,985 | 2430412 |
| 1.07% | INCY | INCYTE CORP | -- | $868,616.36 | 8,573 | 2471950 |
| 1.00% | ILMN | ILLUMINA INC | -- | $810,449.64 | 6,747 | 2613990 |
| 0.91% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $733,499.70 | 18,978 | BMVP7Y0 |
| 0.90% | MEDP | MEDPACE HOLDINGS INC | -- | $731,342.30 | 1,235 | BDCBC61 |
| 0.75% | ROIV | ROIVANT SCIENCES LTD | -- | $609,752.52 | 29,978 | BMW4NZ9 |
| 0.74% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $600,699.06 | 4,351 | 2623911 |
| 0.72% | SNY | SANOFI-ADR | -- | $583,748.55 | 11,781 | 2964557 |
| 0.72% | RVMD | REVOLUTION MEDICINES INC | -- | $578,769.18 | 8,206 | BL71K91 |
| 0.70% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $566,016.20 | 2,668 | BV9G6B8 |
| 0.68% | BBIO | BRIDGEBIO PHARMA INC | -- | $549,749.52 | 8,388 | BK1KWG8 |
| 0.67% | GH | GUARDANT HEALTH INC | -- | $545,235.35 | 5,477 | BFXC911 |
| 0.67% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $542,265.60 | 976 | BD59BS7 |
| 0.67% | SMMT | SUMMIT THERAPEUTICS INC | -- | $540,038.16 | 32,611 | BMTVQS7 |
| 0.66% | VTRS | VIATRIS INC | -- | $535,321.88 | 51,178 | BMWS3X9 |
| 0.64% | ONC | BEONE MEDICINES LTD-ADR | -- | $521,840.25 | 1,475 | BYYWPW6 |
| 0.64% | IONS | IONIS PHARMACEUTICALS INC | -- | $517,482.00 | 6,993 | BDJ0LS6 |
| 0.63% | TEM | TEMPUS AI INC | -- | $511,611.45 | 7,405 | BSLSJJ0 |
| 0.62% | EXEL | EXELIXIS INC | -- | $497,926.24 | 11,816 | 2576941 |
| 0.58% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $468,372.80 | 2,660 | B4Q5ZN4 |
| 0.55% | BNTX | BIONTECH SE-ADR | -- | $447,712.02 | 4,414 | BK6H543 |
| 0.55% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $443,028.24 | 8,429 | 2437071 |
| 0.51% | MRNA | MODERNA INC | -- | $412,994.40 | 17,080 | BGSXTS3 |
| 0.49% | RNA | AVIDITY BIOSCIENCES INC | -- | $400,315.83 | 5,647 | BMWHPY1 |
| 0.45% | HALO | HALOZYME THERAPEUTICS INC | -- | $360,663.50 | 5,134 | 2975098 |
| 0.42% | CYTK | CYTOKINETICS INC | -- | $340,471.45 | 5,255 | BBBSBJ5 |
| 0.40% | AXSM | AXSOME THERAPEUTICS INC | -- | $321,719.84 | 2,192 | BYZR4X4 |
| 0.39% | MRUS | MERUS NV | -- | $318,660.72 | 3,318 | BZBY005 |
| 0.39% | NUVL | NUVALENT INC-A | -- | $313,569.51 | 2,927 | BMVBZD3 |
| 0.37% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $300,991.70 | 2,918 | BF2YWG4 |
| 0.34% | PCVX | VAXCYTE INC | -- | $277,134.00 | 5,700 | BKPVGH6 |
| 0.33% | PTCT | PTC THERAPEUTICS INC | -- | $263,919.60 | 3,491 | B17VCN9 |
| 0.32% | KRYS | KRYSTAL BIOTECH INC | -- | $258,798.80 | 1,268 | BD6JX35 |
| 0.29% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $236,586.87 | 6,071 | BYQBFJ8 |
| 0.29% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $232,319.77 | 2,729 | BDCBCD8 |
| 0.27% | ACLX | ARCELLX INC | -- | $218,045.46 | 2,433 | BPCJ1Q2 |
| 0.26% | COGT | COGENT BIOSCIENCES INC | -- | $214,356.90 | 6,135 | BLR6XK8 |
| 0.26% | ALKS | ALKERMES PLC | -- | $207,945.12 | 7,248 | B3P6D26 |
| 0.25% | KYMR | KYMERA THERAPEUTICS INC | -- | $203,534.80 | 3,140 | BMPRZV5 |
| 0.25% | CRSP | CRISPR THERAPEUTICS AG | -- | $202,361.97 | 3,989 | BDHF4K6 |
| 0.24% | AKRO | AKERO THERAPEUTICS INC | -- | $190,842.08 | 3,512 | BK7Y2V9 |
| 0.24% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $190,821.42 | 4,941 | BP8JSP4 |
| 0.22% | INDV | INDIVIOR PLC | -- | $178,615.40 | 5,479 | BP0BQQ5 |
| 0.22% | LGND | LIGAND PHARMACEUTICALS | -- | $177,615.10 | 862 | 2501578 |
| 0.22% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $177,219.90 | 4,131 | BDD19F8 |
| 0.22% | IMVT | IMMUNOVANT INC | -- | $177,150.84 | 7,649 | BJRFSB7 |
| 0.22% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $175,499.64 | 927 | BQ721R4 |
| 0.21% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $171,078.60 | 7,406 | 2713317 |
| 0.21% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $167,610.87 | 4,223 | BFZQ0L8 |
| 0.21% | ADMA | ADMA BIOLOGICS INC | -- | $167,092.20 | 10,476 | B9NSBM2 |
| 0.20% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $158,826.24 | 13,787 | BFNF1D6 |
| 0.19% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $155,309.18 | 2,205 | BJDX8Y8 |
| 0.18% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $146,840.85 | 5,265 | BKX9VD3 |
| 0.18% | TARS | TARSUS PHARMACEUTICALS INC | -- | $142,730.61 | 1,851 | BMH5RL1 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $142,710.00 | 3,350 | BRBCSP4 |
| 0.17% | GRAL | GRAIL INC | -- | $139,520.42 | 1,586 | BSLSSX7 |
| 0.17% | IRON | DISC MEDICINE INC | -- | $138,650.72 | 1,528 | BMGJZJ8 |
| 0.17% | TVTX | TRAVERE THERAPEUTICS INC | -- | $138,531.30 | 3,910 | BLFGJD5 |
| 0.17% | VCYT | VERACYTE INC | -- | $137,878.29 | 3,453 | BFTWZY0 |
| 0.17% | XENE | XENON PHARMACEUTICALS INC | -- | $137,518.95 | 3,383 | BRJ3GY4 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $134,863.38 | 4,233 | BJ62Z18 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $131,685.82 | 13,534 | B19FQ48 |
| 0.16% | APGE | APOGEE THERAPEUTICS INC | -- | $129,383.41 | 2,027 | BM9HHL5 |
| 0.16% | DYN | DYNE THERAPEUTICS INC | -- | $128,626.40 | 6,244 | BN15WD1 |
| 0.16% | IDYA | IDEAYA BIOSCIENCES INC | -- | $127,351.72 | 3,844 | BK0VHF6 |
| 0.15% | MLYS | MINERALYS THERAPEUTICS INC | -- | $122,695.56 | 2,913 | BP9N0G0 |
| 0.15% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $117,824.00 | 4,208 | BLB0YQ9 |
| 0.14% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $112,650.50 | 2,465 | B72ZBG4 |
| 0.13% | DNLI | DENALI THERAPEUTICS INC | -- | $108,660.24 | 6,422 | BD2B4V0 |
| 0.13% | APLS | APELLIS PHARMACEUTICALS INC | -- | $107,889.15 | 5,547 | BYTQ6X1 |
| 0.13% | TERN | TERNS PHARMACEUTICALS INC | -- | $104,086.56 | 3,838 | BMDJ0C9 |
| 0.13% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $103,404.00 | 3,693 | BMX9K07 |
| 0.13% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $103,300.16 | 4,624 | BKY5JZ8 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $101,247.45 | 6,683 | BJ5FZ74 |
| 0.12% | AVDL | AVADEL PHARMACEUTICALS | -- | $98,429.10 | 4,261 | BDGMC59 |
| 0.12% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $95,583.18 | 2,618 | BQS9486 |
| 0.12% | BEAM | BEAM THERAPEUTICS INC | -- | $93,235.12 | 4,444 | BK6L288 |
| 0.11% | OCUL | OCULAR THERAPEUTIX INC | -- | $92,407.70 | 7,637 | BNZB1X8 |
| 0.11% | IBRX | IMMUNITYBIO INC | -- | $88,799.30 | 41,495 | BNSP0B8 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $87,856.00 | 5,780 | BFWLC09 |
| 0.11% | VCEL | VERICEL CORP | -- | $86,196.35 | 2,213 | BSBMN89 |
| 0.10% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $84,007.82 | 2,522 | BKSGZN7 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $80,441.28 | 1,908 | BRXB0C0 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $79,940.00 | 2,800 | BL55460 |
| 0.10% | TXG | 10X GENOMICS INC-CLASS A | -- | $78,656.90 | 5,026 | BKS3RS7 |
| 0.09% | ANIP | ANI PHARMACEUTICALS INC | -- | $76,474.16 | 952 | BCDWBX6 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $76,000.78 | 2,638 | BMFX8Y7 |
| 0.09% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $75,598.77 | 18,759 | BM9FJ13 |
| 0.09% | ZYME | ZYMEWORKS INC | -- | $74,580.00 | 3,300 | BPCQZY9 |
| 0.09% | ALVO | ALVOTECH SA | -- | $71,844.51 | 13,737 | BPNTJ34 |
| 0.09% | SRPT | SAREPTA THERAPEUTICS INC | -- | $70,362.27 | 4,293 | B8DPDT7 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $68,551.36 | 2,407 | BJQ05Z6 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $67,946.70 | 1,758 | BLCD809 |
| 0.08% | QURE | UNIQURE NV | -- | $67,499.25 | 2,415 | BJFSR88 |
| 0.08% | TWST | TWIST BIOSCIENCE CORP | -- | $67,417.05 | 2,649 | BGKG6G7 |
| 0.08% | MNKD | MANNKIND CORP | -- | $67,355.00 | 13,471 | BF081J4 |
| 0.08% | SYRE | SPYRE THERAPEUTICS INC | -- | $64,395.00 | 2,650 | BQBBDY8 |
| 0.08% | HROW | HARROW INC | -- | $64,270.80 | 1,623 | BHNDW86 |
| 0.08% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $63,873.81 | 9,217 | 2100362 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $63,247.35 | 3,785 | BN7Q7R7 |
| 0.08% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $61,546.48 | 1,384 | BX7RSN3 |
| 0.07% | TRVI | TREVI THERAPEUTICS INC | -- | $59,019.84 | 5,346 | BJH9ZN0 |
| 0.07% | ARDX | ARDELYX INC | -- | $58,908.32 | 10,576 | BN89V40 |
| 0.07% | INVA | INNOVIVA INC | -- | $58,896.63 | 2,769 | BDDXF67 |
| 0.07% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $58,523.16 | 3,012 | BMZ4LN0 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $57,393.70 | 2,597 | BMFD115 |
| 0.07% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $57,011.68 | 2,552 | BCBVTX1 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $56,863.30 | 5,146 | BRJZSK0 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $56,248.80 | 1,840 | BBC9WC7 |
| 0.07% | NVCR | NOVOCURE LTD | -- | $56,196.60 | 4,908 | BYSS4X4 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $56,005.52 | 3,911 | BPCK358 |
| 0.07% | PGEN | PRECIGEN INC | -- | $55,184.94 | 13,077 | BKM5C84 |
| 0.06% | INBX | INHIBRX BIOSCIENCES INC | -- | $52,405.32 | 638 | BNSP8K3 |
| 0.06% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $51,780.17 | 2,041 | BNFWZS4 |
| 0.06% | CVAC | CUREVAC NV | -- | $51,599.70 | 9,885 | BN4RD42 |
| 0.06% | URGN | UROGEN PHARMA LTD | -- | $51,373.91 | 2,033 | BZ7PJQ1 |
| 0.06% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $50,275.19 | 7,091 | BLR7H87 |
| 0.06% | XNCR | XENCOR INC | -- | $49,407.41 | 3,133 | BGCYWN8 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $48,927.76 | 4,262 | BKVDFF7 |
| 0.06% | NRIX | NURIX THERAPEUTICS INC | -- | $48,120.14 | 3,358 | BMVLGP2 |
| 0.06% | WVE | WAVE LIFE SCIENCES LTD | -- | $48,049.92 | 6,984 | BYZG9R0 |
| 0.06% | TSHA | TAYSHA GENE THERAPIES INC | -- | $48,007.72 | 11,972 | BNC1BX1 |
| 0.06% | PCRX | PACIRA BIOSCIENCES INC | -- | $48,003.09 | 1,973 | B3X26D8 |
| 0.06% | RLAY | RELAY THERAPEUTICS INC | -- | $47,974.78 | 7,567 | BN2R582 |
| 0.06% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,359.59 | 13,119 | BL53SR3 |
| 0.06% | ORKA | ORUKA THERAPEUTICS INC | -- | $46,346.40 | 1,640 | BKVF0J2 |
| 0.06% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $45,996.90 | 3,110 | BJLKVS6 |
| 0.06% | GRFS | GRIFOLS SA-ADR | -- | $45,571.05 | 5,355 | B8K7T65 |
| 0.06% | ANAB | ANAPTYSBIO INC | -- | $45,559.31 | 1,231 | BDRW1L7 |
| 0.06% | NVAX | NOVAVAX INC | -- | $45,191.52 | 7,128 | BJDQXG4 |
| 0.05% | CSTL | CASTLE BIOSCIENCES INC | -- | $44,005.50 | 1,270 | BKLCWZ3 |
| 0.05% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $43,211.28 | 3,026 | BMGS7L1 |
| 0.05% | KURA | KURA ONCOLOGY INC | -- | $43,129.20 | 3,810 | BYZD465 |
| 0.05% | ZLAB | ZAI LAB LTD-ADR | -- | $43,091.00 | 2,102 | BD9GVY0 |
| 0.05% | RAPP | RAPPORT THERAPEUTICS INC | -- | $43,088.64 | 1,603 | BR3T9B6 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $40,488.80 | 4,887 | BP2P6L0 |
| 0.05% | FTRE | FORTREA HOLDINGS INC | -- | $39,989.32 | 3,983 | BRXYZ57 |
| 0.05% | TBPH | THERAVANCE BIOPHARMA INC | -- | $39,183.30 | 2,210 | BMNDK09 |
| 0.05% | TYRA | TYRA BIOSCIENCES INC | -- | $38,940.66 | 2,343 | BMVNDH9 |
| 0.05% | NTLA | INTELLIA THERAPEUTICS INC | -- | $38,810.40 | 4,710 | BYZM6C2 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $38,613.80 | 11,357 | BMFJJ97 |
| 0.05% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $38,333.54 | 2,711 | BP7KZP7 |
| 0.05% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $37,794.54 | 4,494 | BLB0YH0 |
| 0.05% | ARVN | ARVINAS INC | -- | $37,161.19 | 3,223 | BDZ30Q0 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $36,952.34 | 893 | BL95N25 |
| 0.05% | MNMD | MIND MEDICINE MINDMED INC | -- | $36,549.92 | 3,344 | BPQYY97 |
| 0.04% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $35,940.59 | 8,417 | BZ0QMB7 |
| 0.04% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $35,904.62 | 15,887 | BF0DMK7 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $35,633.37 | 1,779 | BMGTLY5 |
| 0.04% | LENZ | LENZ THERAPEUTICS INC | -- | $35,528.40 | 1,251 | BQV0J03 |
| 0.04% | SVRA | SAVARA INC | -- | $34,918.60 | 7,591 | BYXGN81 |
| 0.04% | ERAS | ERASCA INC | -- | $34,373.04 | 12,454 | BNLYBF3 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $33,167.68 | 6,097 | BK4PZ38 |
| 0.04% | CRMD | CORMEDIX INC | -- | $32,888.37 | 3,279 | BJ0LT31 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $32,885.52 | 789 | BQD3J33 |
| 0.04% | PSNL | PERSONALIS INC | -- | $32,070.08 | 3,892 | BJQ0608 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $30,939.81 | 5,307 | BYVQJ96 |
| 0.04% | ATXS | ASTRIA THERAPEUTICS INC | -- | $30,838.76 | 2,479 | BMYRFN8 |
| 0.04% | REPL | REPLIMUNE GROUP INC | -- | $30,826.71 | 3,429 | BDDVW37 |
| 0.04% | SPRY | ARS PHARMACEUTICALS INC | -- | $30,749.33 | 4,337 | BMCR7V2 |
| 0.04% | MESO | MESOBLAST LTD- SPON ADR | -- | $30,739.50 | 2,070 | BQS7491 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $30,285.39 | 2,209 | BD06CS0 |
| 0.04% | GERN | GERON CORP | -- | $30,247.56 | 28,007 | 2370381 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $30,010.80 | 1,780 | BM7V485 |
| 0.04% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $29,138.60 | 3,274 | BYP80F1 |
| 0.04% | PRME | PRIME MEDICINE INC | -- | $28,562.16 | 7,678 | BPBJFM7 |
| 0.03% | ALMS | ALUMIS INC | -- | $27,942.21 | 4,253 | BPLQG36 |
| 0.03% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $26,757.40 | 3,530 | BFYQFJ2 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $24,699.87 | 8,853 | BBNBTD2 |
| 0.03% | OMER | OMEROS CORP | -- | $24,569.58 | 2,989 | B4NB858 |
| 0.03% | RGNX | REGENXBIO INC | -- | $24,209.95 | 2,215 | BZ0G875 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $23,880.56 | 2,467 | BLFBZ32 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $23,586.39 | 2,361 | B91XRN2 |
| 0.03% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $23,209.12 | 13,187 | B4N8MH9 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $23,136.20 | 15,956 | BWFZX59 |
| 0.03% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $22,667.04 | 7,128 | B3MZ6K5 |
| 0.03% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $22,239.00 | 6,354 | BMCWKZ2 |
| 0.03% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $22,140.00 | 2,050 | BKLXFX5 |
| 0.03% | CGEM | CULLINAN THERAPEUTICS INC | -- | $21,885.50 | 2,590 | BM90J52 |
| 0.03% | LXEO | LEXEO THERAPEUTICS INC | -- | $21,525.12 | 2,368 | BQ6C357 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $21,141.75 | 4,027 | BMC3HS7 |
| 0.02% | HCM | HUTCHMED CHINA-ADR | -- | $19,833.45 | 1,365 | BYXV9H7 |
| 0.02% | ANNX | ANNEXON INC | -- | $19,589.50 | 4,825 | BMVV9R5 |
| 0.02% | GLPG | GALAPAGOS NV-SPON ADR | -- | $19,269.68 | 632 | B292NQ7 |
| 0.02% | EOLS | EVOLUS INC | -- | $19,268.76 | 2,842 | BDRJH21 |
| 0.02% | ABSI | ABSCI CORP | -- | $18,781.62 | 6,567 | BN94K69 |
| 0.02% | SIGA | SIGA TECHNOLOGIES INC | -- | $18,581.04 | 3,144 | 2107437 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $18,342.66 | 2,499 | BMFK3H6 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $18,056.86 | 7,109 | BN4JN37 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $17,790.84 | 3,876 | BFY7DC4 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $15,628.77 | 1,899 | BSMLR16 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $15,383.20 | 820 | BPBPCG8 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $15,326.08 | 3,421 | BQHN6C7 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $15,010.32 | 884 | BN72KB0 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $14,715.00 | 2,725 | BP81R42 |
| 0.02% | TRDA | ENTRADA THERAPEUTICS INC | -- | $14,596.56 | 1,672 | BP81RK8 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $14,585.34 | 847 | BTNMG41 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $13,749.84 | 4,407 | BZC0D70 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $13,651.20 | 4,740 | BDFKQ07 |
| 0.02% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $13,561.20 | 3,767 | BYTYP72 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $13,317.74 | 2,591 | B12W3P6 |
| 0.02% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $13,252.23 | 2,061 | BL5B6Z1 |
| 0.02% | NGNE | NEUROGENE INC | -- | $13,223.70 | 630 | BS2F741 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $13,029.85 | 3,755 | BMXNGZ6 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $12,700.00 | 2,032 | BKDQKM6 |
| 0.02% | PYXS | PYXIS ONCOLOGY INC | -- | $12,434.97 | 2,721 | BLBR8D5 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $12,273.66 | 9,741 | BFZNYB7 |
| 0.01% | FHTX | FOGHORN THERAPEUTICS INC | -- | $12,067.38 | 2,483 | BMF7DT9 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $11,402.20 | 940 | B9L5200 |
| 0.01% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $11,181.08 | 8,804 | BFMLGR4 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $10,984.05 | 3,487 | BLN9Z50 |
| 0.01% | TKNO | ALPHA TEKNOVA INC | -- | $10,382.58 | 2,349 | BP7L561 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $10,121.28 | 2,433 | BY7RB53 |
| 0.01% | EDIT | EDITAS MEDICINE INC | -- | $9,951.48 | 3,949 | BZ8FPH3 |
| 0.01% | OABI | OMNIAB INC | -- | $8,881.95 | 5,383 | BN13S71 |
| 0.01% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,186.75 | 1,145 | BQB9HM8 |
| 0.01% | HUMA | HUMACYTE INC | -- | $8,136.18 | 6,954 | BMYTJP4 |
| 0.01% | PEPG | PEPGEN INC | -- | $7,979.79 | 1,443 | BMTX3D7 |
| 0.01% | MXCT | MAXCYTE INC | -- | $7,957.70 | 4,681 | BKMQF66 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,817.50 | 3,127 | BKX9NQ0 |
| 0.01% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $7,187.60 | 1,190 | BKC9SX3 |
| 0.01% | CDXS | CODEXIS INC | -- | $6,418.44 | 3,962 | B5LL2C2 |
| 0.01% | MRSN | MERSANA THERAPEUTICS INC | -- | $6,046.59 | 219 | BVPKH99 |
| 0.01% | NKTX | NKARTA INC | -- | $5,588.38 | 3,122 | BK80YJ8 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,479.52 | 2,978 | BMW5LX6 |
| 0.01% | ALEC | ALECTOR INC | -- | $5,424.12 | 4,446 | BJ4LDC4 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $5,315.10 | 5,062 | BCZS820 |
| -- | PLRX | PLIANT THERAPEUTICS INC | -- | $4,045.50 | 2,697 | BMDWW66 |
| -- | MGNX | MACROGENICS INC | -- | $3,941.92 | 2,776 | BFDV8K0 |
| -- | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $3,881.47 | 8,637 | BPG5P75 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $3,644.25 | 1,075 | BMF1LJ7 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $3,387.93 | 3,723 | BF12XC2 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $3,261.52 | 1,382 | BP2TPK4 |
| -- | BMEA | BIOMEA FUSION INC | -- | $2,876.50 | 2,615 | BNKF6N0 |
| -- | TCRX | TSCAN THERAPEUTICS INC | -- | $2,369.00 | 2,300 | BNLYBJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $1,796.64 | 6,304 | BJL38Z1 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,562.16 | 566 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $1,129.96 | 533 | BS2FKQ4 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| 38.01% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 30,765,357 | -- | 5,535 | -- |
| 35.00% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 28,325,250 | -- | 5,096 | -- |
| 21.12% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 17,091,865 | -- | 3,075 | -- |
| 17.06% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 13,806,892 | -- | 2,484 | -- |
| 15.79% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 12,778,601 | -- | 2,299 | -- |
| 7.93% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 6,419,871 | -- | 1,155 | -- |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $27,658,701.71 | 27,658,702 | -- |
Index
as of 9/30/2025
- Total Number of Companies251
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$6.56 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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